Pilot Plant Retooling for a More Reliable Process Scale-up

Piloting a new process at a smaller scale before rolling it out to the larger manufacturing facility presents numerous scale-down as well as scale-up challenges. This paper will focus on several case studies to illustrate best practices we learned through experience for a successful scale-up. The paper will cover the following case studies –

1. Improving liquid-liquid separation through the use of a coalescer centrifuge and scale-up of the same
2. Lowering the contamination of polymer with residual monomer through modifications in reactor design.
3. Enhancing pilot plant capability through the use of a concentrator