Woo Sik Choi1, Peter Balaz2, Erika Godocikova3, Min Jae Seong4, Bong June Cha4, Gyu-Jeong Noh5, Byung-Moon Choi5, and Peter Jr. Balaz6. (1) Department of Pharmaceutical Manufacturing, Pusan National University, 30 Jangjeon-dong,, Geumjeong-gu,, Busan, 609-735, South Korea, (2) Department of Mechanochemistry, Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Kosice, 043 53, Slovak Republic, (3) Institute of Geotechnics, Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, Kosice, 043 53, Slovak Republic, (4) Interdisciplinary Program in Powder Technology, Graduate School, Pusan National University, Jangjeon-dong,, Geumjeong-gu, Busan, 609-735, South Korea, (5) Asan Medical Center, University of Ulsan, Gwangjin-gu, Seoul, 138-736, South Korea, (6) Institute of Clinical and Experimental Medicine, 140 21, Prague, 4, Czech Republic
The mechanochemical transformation of ƒÑalfa-realgar As4S4 to its high temperature polymorph ƒ"beta- form has been studied. The size dependance of this transformation was elucidated for particle size 25-62 nm. The mechanochemical transformation is hindered by agglomeration effects in this case. The identified phenomena - polymorphous transformation, new surface area formation and preparation of realgar particles in nanosize - are expected to have good impact on solubility as well as bioavailability of realgar as a potential new pharmaceutical drug for leukemia treatment.
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