544184 Epigenome Remodelling in Cancer

Thursday, October 4, 2018: 9:00 AM
Susan Clark, Garvan Institute of Medical Research, Darlinghurst, Australia

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. We performed Hi-C chromosome conformation capture and replication timing sequencing to investigate how three-dimensional chromatin organization in relation to the epigenome is disrupted in cancer. Our study provides new insights into the relationship between replication timing, long-range epigenetic deregulation and changes in higher-order chromatin interactions in cancer.

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