296 Complex Biomolecule Isolation and Clearance

Monday, November 16, 2020: 8:00 AM - 9:00 AM
Separations Division (02) (PreRecorded+)

Description:
Next-generation therapeutics, including proteins (bispecific antibodies, therapeutic enzymes, CRISPR-Cas nucleases), viral vectors for gene therapy, and cells (stem cells, engineered T cells, etc.) are a new and exciting class of biotherapeutics. They are the way of the future. To enable this future, it is crucial to develop novel technologies for their isolation, purification, and clearance from natural (animals or plants) or recombinant sources (cell culture fluids). A broad variety of topics are welcome: novel ligands and substrates, mobile phases and separation approaches (chromatographic vs.non-chromatographic), computational models, application of imaging and sensing techniques, and quality-by-design. To bioseparations of the future and beyond!!!

Sponsor:
Bio Separations
Co-Sponsor(s):
Chemical Engineers in Medicine (TF)
Chair:
Stefano Menegatti Email: smenega@ncsu.edu
Co-Chair:
Ketki Behere Email: ketkipalkar@gmail.com


(296a) A Biophysical Outlook of Viral Inactivation with Arginine and Common Buffers in Biologics Manufacturing
Pratik U. Joshi, Christa Meingast, Xuankuo Xu, Melissa Holstein, Hasin Feroz, Swarnim Ranjan, Sanchayita Ghose and Caryn L. Heldt


(296b) The Effects of Filtration Flux on the Clearance of Minute Virus of Mice during Viral Filtration
Namila Khereid, Rong Fan, Dharmesh Kanai, Mi Jin, Ranil Wickramasinghe and Xianghong Qian


(296c) Outside-in Hemodialysis: A Study of Toxin Clearance
Farzad Mohajerani, Thomas Kelly, Mohamed Labib, William R. Clark and Vivek Narsimhan




(296f) Apohemoglobin Haptoglobin Complexes Attenuate the Hypertensive Response to Low Molecular Weight Polymerized Hemoglobin
Donald Belcher, Carlos Munoz, Alexander Williams, Ivan Pires, Pedro Cabrales and Andre Palmer
See more of this Group/Topical: Separations Division