599438 Development of Process Models and Control Strategies to Support the Continuous Manufacturing of Pharmaceuticals

Tuesday, November 17, 2020
Meet the Industry Candidates Poster Session (T1) (Poster Gallery)
Andrew J. Maloney, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA

Research Interests

Throughout my PhD I have worked on the advancement of modeling and control for the continuous manufacturing of pharmaceuticals. I have been the primary contributor on three main projects and a secondary contributor on a few others.

The first of these projects focused on the development of a virtual plant for the manufacturing of a small molecule active pharmaceutical ingredient. The plant was used to inform process design and process control for the manufacturing system.

The second of these projects focused on the development of a model for the production of recombinant proteins in the host, Pichia pastoris. The model was validated with existing literature and used to understand long-term process stability and explored methods to analyze and increase this stability.

The third of these projects involves on construction of a testbed for the continuous manufacturing of monoclonal antibodies. The system is heavily instrumented so that diverse datasets can be generated for process model and control strategy development. For this, I have worked on data integration, control strategy development, and process modeling for the system.

Outside of these projects, I have a working knowledge of viral vector (specifically recombinant adeno-associated viruses) and vaccine manufacturing. I am looking for a job to leverage my experience in process modeling and control for the advancement of pharmaceutical manufacturing processes.


Extended Abstract: File Uploaded