CRISPR-Cas Systems Mediated Electrochemical Biosensing Platforms

Robust developments of personalized medicine for next-generation healthcare highlight the need for sensitive and accurate point-of-care platforms for quantification of disease biomarkers. Broad presentations of clustered regularly interspaced short palindromic repeats (CRISPR) as an accurate gene editing tool indicate that the high-specificity and programmability of CRISPR system can be utilized as a powerful biosensing tool. Herein, we introduce how CRISPR-Cas systems can modulate electrochemical biosensing platforms toward sensitivity, accuracy and programmability. The presented examples demonstrate the potential of CRISPR-Cas systems based biosensing platforms for the development of ideal integrated point-of-care devices.