788 Materials Science in Pharmaceutical Process Development II

Friday, November 18, 2016: 3:15 PM - 5:45 PM
Continental 5 (Hilton San Francisco Union Square)
Description:
Material science understanding is a key factor to consider in drug substance and drug product process development. The material properties for the API, excipients, and intermediates can influence the process and product performance. This session focuses on the application of material science to guide drug substance and drug product development. Of particular interest is work related to elucidate key material attributes impacting process and product performance as well as the application of the novel material property tool or data to gain further process understanding.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)

Chair:
Shrikant Khot
Email: snkhot@dow.com

Co-Chair:
Bei Chen
Email: bei.chen@abbvie.com


3:15 PM
(788a) In silico Formulation Development of Oral Solid Dosage Forms Using a Material Property Database
Maxx Capece, Ping Gao, Raimundo Ho, David O'Brien, Ahmad Sheikh, John C. Strong and Divya Sunkara

3:35 PM
(788b) Prediction of Tablet Dissolution from API and Excipient Polymer Properties
Jaime Curtis-Fisk, True Rogers,, Karen Balwinski, Kathryn Hewlett, Robert Schmitt and Shrikant Khot

4:15 PM
(788d) Decoupling of a Low-Dose Dosator Capsule Filling Process in Dynamic and Static Mode Tests to Understand the Extend of the Effect of Powder and Process Parameters on Capsule Quality Attributes
Eva Faulhammer, Sandra Stranzinger, Peter Loidolt, Vittorio Calzolari, Stefano Biserni, Stanko Srčič, Rok Dreu, Amrit Paudel and Johannes G. Khinast

4:55 PM
(788f) Two-Phase Flow (solids: interstitial air) Modeling of a Press Feed System
Thomas Baxter, Roger Barnum, James K. Prescott and John Carson

5:15 PM
(788g) Use and Misuse of the Diametrical Compression Test
Jon Hilden, Mark Polizzi and Aaron Zettler