787 Innovations in Biopharmaceutical Discovery, Development, and Manufacturing II

Friday, November 18, 2016: 3:15 PM - 5:45 PM
Continental 4 (Hilton San Francisco Union Square)
Description:
This session will focus on innovations and advances within the biopharmaceutical industry, including, but not limited to, the area of bioprocess development and manufacturing. Topics of interest include: implementation of innovative technologies across scales, new applications of process analytics (PAT), multivariate (MVA) or other statistical analyses, scale-up/scale-down modeling and related concerns, and improvements in process robustness. In addition, process control for optimizing bioreactor performance and product quality control at manufacturing scale will be highlighted.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B), Bioengineering (15C), Bio Separations (02G)

Chair:
Yuguo Lei
Email: ylei14@unl.edu

Co-Chair:
Mo Jiang
Email: mojiang@mit.edu


3:15 PM
(787a) Optimizing Process Yields of a Legacy 25,000L Mammalian Cell Culture Process Using Integrated Upstream and Downstream Process Yield Models
Simpson Gregoire, Jessica Woodman, Sivaprakash Agastin, Sivashankar Sivakollundu and Jeffrey Savard

3:37 PM
(787b) Intelligent Control Strategies Towards the Intensification of Monoclonal Antibody Production Via Continuous Operation
Maria M. Papathanasiou, A. Mantalaris and Efstratios N. Pistikopoulos

3:59 PM
(787c) Development of a Scalable Process for Production of a Broadly Protective Influenza Antigen
Julie Fogarty, Yuan Lu and James Swartz

4:21 PM
(787d) Application of Process Monitoring Data Management Systems to Make Multiple Incremental Improvements to Cell Cultures Processes at the Manufacturing Scale
Christopher C. VanLang, Erin K. Abbott, June Axelson and Hugh Graham

4:43 PM
(787e) Scalable Production of Glioblastoma Cancer Stem Cells in 3 Dimension Thermoreversible Hydrogels for Drug Discovery
Qiang Li, Yuguo Lei, Haishuang Lin and Ou W Ang

5:05 PM
(787f) Levers to Modulate Product Quality Attributes of Product-a in CHO Cell Culture
Jayashree Subramanian, Abigail Pynn and Lauren Tang

5:27 PM
(787g) Data-Driven Optimization Using an Evolutionary Design of Dynamic Experiments for Biopharmaceutical Processes
Zhenyu Wang and Christos Georgakis
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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