44 Particle Engineering As Applied to Pharmaceutical Formulations

Sunday, November 13, 2016: 3:30 PM - 6:00 PM
Peninsula (Hotel Nikko San Francisco)
Description:
This session seeks papers whose scope is within the broadly defined area of Particle Engineering as applied to Pharmaceutical Systems. Pharmaceutical dosage forms entail the design of active pharmaceutical ingredients (APIs) and excipients in such a way to achieve controllable, reproducible, and effective functional responses (release rate, location of delivery, taste-masking, etc.) of the APIs in human body. These functional responses greatly depend on the dosage form and the way API and excipient particles are integrated into the superstructure of the dosage form. Particle engineering offers tools and methodologies, both experimental and numerical, to design the structure of particles so that the desired responses of the API are enhanced significantly in the dosage form. Particles and their surfaces can be designed and tailored in many different processes via different formulation approaches. Both novel formulations and the manufacturing processes that yield engineered particles are of interest to this session, as well as scientific approaches that relate particle formation, structure and functional performance. Papers can be experimental in nature, while fundamental theoretical or modeling works (e.g. based on DEM, FEM or CFD) providing insight into the formation and behavior of the particles in the dosage form are also welcome.

Sponsor:
Particle Production and Characterization
Co-Sponsor(s):
Pharmaceutical Discovery, Development and Manufacturing Forum (26)

Chair:
Ilgaz Akseli
Email: iakseli@celgene.com

Co-Chair:
Ecevit Bilgili
Email: bilgece@njit.edu

- indicates paper has an Extended Abstract file available on the online proceeding.


3:30 PM
(44a) Maximizing Poorly Water-Soluble API Nanoparticle Loading in Polymer Strip Films
Scott M. Krull, Meng Li, Ecevit Bilgili and Rajesh N. Davé

3:49 PM
(44b) Computational Approaches for Modeling Fluid Bed Granulation Process
Gulsad Kucuk, Robert Schwabe, Leon Schultz and Ilgaz Akseli

4:08 PM
(44c) Comparison of the Electrostatic Properties of Amorphous and Crystalline Lactose
Karolina Biegaj, Tim Lukas, Martin Rowland and Jerry Heng

4:27 PM
(44d) Particle Engineering Research from the NSF Erc Research Experience for Teachers (RET) Program at Njit
Ecevit Bilgili, Meng Li, Lu Zhang, Mina Armani, Paul Orbe, Marie Aloia, Barbara Pielecha-Safira and Rajesh N. Dave

5:05 PM
(44f) The Surface Properties of Organic Crystalline Solids and Their Interactions with Polymeric Excipients and Binders
Mark A. Isbell, Eftychios Hadjittofis, Steven J. Hinder, Geoff G. Z. Zhang and Jerry Heng
File available
5:24 PM
(44g) Narrow Tube Spray Drying with Precise Drying History Control for Particle Engineering
May Ginn (Jaclyn) Lee, Shahnaz Mansouri, Karen Hapgood and Meng Wai Woo

5:43 PM
(44h) Soluble Tag-Assisted Liquid-Phase Peptide Synthesis Using Hydrophobic Benzyl Alcohols
Yingzi Liu, Yohei Okada, Kazuhiro Chiba and Hidehiro Kamiya
See more of this Group/Topical: Particle Technology Forum