165 Model Based Integrated Design of Pharmaceutical Drug Substance Processes

Monday, November 14, 2016: 12:30 PM - 3:00 PM
Continental 5 (Hilton San Francisco Union Square)
Description:
This session seeks contributions showcasing the development and implementation of first-principles as well as data-driven process modeling, simulation and optimization methods for design and development of pharmaceutical processes for the production of key intermediates and APIs. Modeling approaches including CFD, DEM, FEM, PBM, Monte Carlo and other methods, or a focus on thermodynamic, kinetic and transport parameter estimation, are welcome. Authors are encouraged to highlight Quality by Design (QbD) mapping approaches, process integration and intensification achievements, process economics and environmental impact analyses.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)

Chair:
Dimitrios I. Gerogiorgis
Email: D.Gerogiorgis@ed.ac.uk

Co-Chair:
Samrat Mukherjee
Email: samrat.mukherjee@abbvie.com


12:30 PM
(165a) Multi-Scale Modeling in Pharmaceutical Drug Substance Manufacturing
José L.C. Santos, Rui C. Silva and Filipe A.P. Ataíde

12:50 PM
(165b) A Simultaneous Approach for Kinetic Parameter Estimation and Curve Resolution Based on Spectroscopic Measurements
Lorenz Biegler, Weifeng Chen and Salvador García-Muñoz

1:10 PM
(165c) Application of Computational Chemistry in Pharmaceutical Process Development
Dimitri Skliar and Antonio Ramirez

1:30 PM
(165d) Systematic Optimisation of Continuous Separation for Artemisinin Recovery in Continuous Pharmaceutical Manufacturing
Hikaru G. Jolliffe and Dimitrios I. Gerogiorgis

1:50 PM
(165e) Prediction of Liquid-Liquid Partitioning and Solubility of APIs with the SAFT-γ Mie Approach
Panatpong Hutacharoen, Simon Dufal, Vasileios Papaioannou, Claire S. Adjiman, George Jackson and Amparo Galindo

2:10 PM
(165f) Use of a First Principles Model during QbD Studies to Assess Impurity Formation for a Coupling Reaction
Billie Kline, Conrad Fung, Elaine Lee and David Willcox

2:30 PM
(165g) Verification and Use of CFD Modeling in Stirred Tank Reactors for Pharmaceutical Applications
Andrew Glace, Divya Seshadri, Fulya Akpinar and Benjamin Cohen

2:50 PM
(165h) Product-Agnostic Computational Fluid Dynamic (CFD) Model for Single-Use Mixing System
Ahsan Munir, Sean Fitzgibbon, Kenroy Noicely, Alan Dominguez, Adam Sokolnicki and Cenk Undey
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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