165 Model Based Integrated Design of Pharmaceutical Drug Substance Processes

Monday, November 14, 2016: 12:30 PM - 3:00 PM
Continental 5 (Hilton San Francisco Union Square)
Description:
This session seeks contributions showcasing the development and implementation of first-principles as well as data-driven process modeling, simulation and optimization methods for design and development of pharmaceutical processes for the production of key intermediates and APIs. Modeling approaches including CFD, DEM, FEM, PBM, Monte Carlo and other methods, or a focus on thermodynamic, kinetic and transport parameter estimation, are welcome. Authors are encouraged to highlight Quality by Design (QbD) mapping approaches, process integration and intensification achievements, process economics and environmental impact analyses.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)

Chair:
Dimitrios I. Gerogiorgis
Email: D.Gerogiorgis@ed.ac.uk

Co-Chair:
Samrat Mukherjee
Email: samrat.mukherjee@abbvie.com


12:30 PM
(165a) Multi-Scale Modeling in Pharmaceutical Drug Substance Manufacturing
José L.C. Santos, Rui C. Silva and Filipe A.P. Ataíde

1:50 PM
(165e) Prediction of Liquid-Liquid Partitioning and Solubility of APIs with the SAFT-γ Mie Approach
Panatpong Hutacharoen, Simon Dufal, Vasileios Papaioannou, Claire S. Adjiman, George Jackson and Amparo Galindo

2:30 PM

2:50 PM
(165h) Product-Agnostic Computational Fluid Dynamic (CFD) Model for Single-Use Mixing System
Ahsan Munir, Sean Fitzgibbon, Kenroy Noicely, Alan Dominguez, Adam Sokolnicki and Cenk Undey