766 Particle Engineering As Applied to Pharmaceutical Formulations II

Friday, November 18, 2016: 8:30 AM - 11:00 AM
Continental 5 (Hilton San Francisco Union Square)
This session seeks papers within the scope of particle engineering of active pharmaceutical ingredients (APIs) and excipients to enable pharmaceutical formulation design and development. The manufacturability and performance of a formulation can be greatly affected by the nature of the excipients and APIs (physical properties, physical and chemical stability), as well as the interactions of these components. The efficient development of pharmaceutical drug product formulations requires the design of fit for purpose APIs and excipients in such a way to achieve robust and reproducible manufacturability, as well as the critical quality attributes (CQAs) of safety, quality and efficacy of the drug product. Particle engineering offers tools and methodologies, both experimental and numerical, to design particles e.g. via different crystallization, co-processing and formulation approaches. Both novel manufacturing processes and formulations that yield engineered particles are of interest to this session. Also, scientific approaches that relate particle formation, structure and functional performance are welcome. Experimental as well as fundamental, theoretical or modeling works (e.g. based on DEM, FEM or CFD) that provide insight into the formation and behavior of the particles in the dosage form are also encouraged.

Pharmaceutical Discovery, Development and Manufacturing Forum
Particle Production and Characterization (03A), Pharmaceuticals (15B)

Dolapo Olusanmi
Email: dolapo.olusanmi@bms.com

Ecevit Bilgili
Email: bilgece@njit.edu

- indicates paper has an Extended Abstract file available on the online proceeding.

8:30 AM

9:21 AM
(766d) 'designer' Hydrogel Particles for Controlled Crystallization and Release of Hydrophobic Active Pharmaceutical Ingredients
Abu Zayed Md Badruddoza, P. Douglas Godfrin, Allan S. Myerson, Bernhardt L. Trout and Patrick S. Doyle
File available
9:38 AM
(766e) Dissolution of Carbamazepine Crystallized Directly Onto Excipients
Vivek Verma, Clare M. Crowley, Peter Davern, Sarah Hudson and B. Kieran Hodnett

9:55 AM
(766f) Modeling Spray Dried Dispersion: From Droplet to Particle
Jaime Curtis-Fisk, Priti Jain, Jodi Mecca, Bart Rijksen, Shrikant Khot and William Porter III

10:29 AM
(766h) A Novel Method for Grindability Assessment of Pharmaceutical Powders
Tina Bonakdar, Muzammil Ali, Mojtaba Ghadiri and Arjen Tinke