780 Materials Science in Pharmaceutical Process Development I

Friday, November 18, 2016: 12:30 PM - 3:00 PM
Continental 5 (Hilton San Francisco Union Square)
Description:
Material science understanding is a key factor to consider in drug substance and drug product process development. The material properties for the API, excipients, and intermediates can influence the process and product performance. This session focuses on the application of material science to guide drug substance and drug product development. Of particular interest is work related to elucidate key material attributes impacting process and product performance as well as the application of the novel material property tool or data to gain further process understanding.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)

Chair:
Bei Chen
Email: bei.chen@abbvie.com

Co-Chair:
Shrikant Khot
Email: snkhot@dow.com


12:30 PM
(780a) Investigation of the Dfferences in Material Properties Between Amorphous Dispersions Created By Conventional Methods and High-Shear Co-Precipitation
Athanas Koynov, Luke Schenck, Narayan Variankaval, Andrew Brunskill, Amanda Mann, Yongjun Li, Dina Zhang, Dirk Stueber and Paul Walsh

12:50 PM
(780b) Melt Rheology of Cellulose Ethers Designed for Hot Melt Extrusion
Tirtha Chatterjee, Kevin O'Donnell, Yongfu Li, Uma Shrestha, Robert Sammler and Shrikant Khot

1:30 PM
(780d) A Kinetic Approach to Polymorph Prediction: Polymorph Specific Alpha and Beta Glycine Nucleation Rates and Solubility Curves from Molecular Dynamics
Conor Parks, Andy Koswara, Hsien-Hsin Tung, Nandkishor Nere, Shailendra Bordawekar, Zoltan K. Nagy and Doraiswami Ramkrishna

2:10 PM
(780g) Raman Mapping for Analyzing Multi-Component Solid Dosage Formulations
Zhen Liu, Haichen Nie, Patrick Marsac, Brian Marks, Wei Xu and Anthony Leone