284 Continuous Processing in the Manufacture of Pharmaceuticals: Drug Substance (In memory of Tom LaPorte)

Tuesday, November 15, 2016: 8:30 AM - 11:00 AM
Continental 4 (Hilton San Francisco Union Square)
Description:
Enabled by new technology, continuous processing offers new methods of increasing safety, selectivity, and yield for chemical and biochemical processes. Improved control over process streams enables operation at extreme conditions with reduced sensitivity to scale-up effects. This session will focus on applications of continuous processing to the production of drug substances or their intermediates. The session is keen to attract papers which provide an insight to continuous processing state of the art and its association to industrial application.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)

Chair:
Dimitri Skliar
Email: dimitri.skliar@bms.com

Co-Chair:
Mark Barrett
Email: mark.barrett@approcess.com


8:52 AM
(284b) The Development of Integrated Continuous Drug Substance Processes
Jessica Whelan, Mark Barrett and Brian Glennon

9:14 AM

9:36 AM
(284e) Designing for Continuous: A Step Change in Performance
Philip Donnellan, Roderick Jones and Brian Glennon

9:58 AM
(284f) Continuous Drying of Powders and Slurries in an Extruder without Changing Product Particle Size Distribution
Manuel Kreimer, Isabella Aigner, Gerold Koscher, Daniel Lepek and Johannes G. Khinast

10:20 AM
(284g) Continuous Co-Crystallization of Novel Theophylline and 4-Aminobenzoic Acid Co-Crystals from Twin Screw Extrusion
Rahamatullah Shaikh, Shaza Darwish, Manuel Kuhs, Ahmad B. Albadarin, Denise Croker and Gavin Walker