713 Solid Form Selection: Cocrystals, Salts, Solvates, Polymorphs, and Beyond

Thursday, November 17, 2016: 12:30 PM - 3:00 PM
Cyril Magnin I (Parc 55 San Francisco)
Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.

Sponsor:
Crystallization and Evaporation

Chair:
Meenesh R. Singh
Email: mrsingh@lbl.gov

Co-Chair:

12:30 PM
Introductory Remarks

12:35 PM
(713a) Improving the Search for Polymorphs
Isaac Sugden, Claire Adjiman, Costas Pantelides and Manolis Vasileiadis

12:55 PM
(713b) Polymorph Selection By Continuous Crystallization
Thomas Farmer, Corinne Carpenter and Michael F. Doherty

1:15 PM
(713c) Coarse-Grained Drug Molecule Simulation and Polymorph Discovery
Ryan L. Marson, Taraknath Mandal and Ronald G. Larson

1:35 PM
(713d) Nanocrystal Dissolution Kinetics and Solubility Increase from Molecular Dynamics – the Case of Alpha and Beta Glycine
Conor Parks, Andy Koswara, Hsien-Hsin Tung, Nandkishor Nere, Shailendra Bordawekar, Zoltan K. Nagy and Doraiswami Ramkrishna

2:35 PM

2:55 PM
Concluding Remarks
See more of this Group/Topical: Separations Division