480752 Biodegradable Polymer-Drug Conjugates for pH-Sensitive Anti-Cancer Drug Delivery

Monday, November 14, 2016
Grand Ballroom B (Hilton San Francisco Union Square)
Alex Commisso, Meghan Capeling, Zachary Manzer, Patrick Krohl, Haotian Sun and Chong Cheng, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY

Polymer-drug conjugates represent a selective and novel chemotherapy approach for cancer treatment. Polycaprolactone and polylactide were chosen as the building blocks for drug delivery systems because of their biodegradability. Accordingly, two ester-based monomers with an acetylene or allyl group were designed to allow for the attachment of anti-cancer drugs and solubility-enhancing groups with the resulting polymers. The anti-cancer drugs, doxorubicin and paclitaxel, were conjugated with the polymer chains using pH-sensitive linkages. Novel “click chemistries” were utilized throughout the synthesis of the polymer-drug conjugates. Precursors of the conjugates have been obtained with sufficient yields and characterized using nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography (GPC).

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