480518 PLGA Encapsulation of Apocynin

Monday, November 14, 2016
Grand Ballroom B (Hilton San Francisco Union Square)
Seth Baetzold, Allan Lee and Ashley Yong, Chemical Engineering, Iowa State University, Ames, IA

Drug delivery to the brain is a challenging task due to the blood brain barrier. PLGA is a biopolymer commonly used as a biodegradable drug delivery carrier. Study of the degradation of PLGA encapsulated drug is useful for drug applications. The drug Apocynin is used to treat Parkinsons. Apocynin is an anti-inflammatory drug used to treat colitis. The size and zeta potential of the encapsulated drug is of importance since passing blood brain barrier and mimicking human body conditions in essential for the drug encapsulated particle to operate correctly. In this experiment different concentrations of PLGA and APO are tested for size, zeta and concentration degradation. The particles are engineered by adjusting the concentration ratio of APO to PLGA. The optimal particle size for particles are 100 to 200 nm. The optimal formulation of particles is sought from the size, zeta, and concentration degradation.

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