478623 Development of Nanoparticle Encapsulation for Targeted Drug Delivery
Polylactide-co-glycolide polymer nanoparticles loaded with a model drug were prepared by impingement jets mixing and removal of the solvent using an ultrafiltration stir cell. Sucrose was added to the aqueous nanoparticle solution and the mixture was freeze dried to produce polymer nanoparticle powder. The nanoparticles were loaded into an injectable hydrogel formulation to modulate the controlled release of a model drug. The drug release kinetics of the polymer nanoparticle/hydrogel composite were evaluated in vitro to determine the effect of adding a mass transfer barrier on the rate of drug release from polymer nanoparticles. The use of a hydrogel effectively increased the drug release time from 2 d to 12 d.
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