473007 Novel Zwitterionic Macro-Crosslinker Enhancing Durability of Non-Fouling Coating

Thursday, November 17, 2016: 3:33 PM
Golden Gate 3 (Hilton San Francisco Union Square)
Zhiqiang Cao, Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

For many applications involving surface exposure to biomolecules and microorganisms, biofouling is a serious problem that causes implantable device failure and unwanted microorganism attachment. Recently, surface modification with non-fouling polymers has been utilized to overcome the biofouling problem. Encouraging
results have been obtained in various applications in different traditional substrates such as anti-thrombosis polyurethane catheters and coatings on metal ship hull to resist marine fouling by using non-fouling zwitterionic polymers. Zwitterionic polymer coatings are super-hydrophilic and attract a dense layer of water molecules to resist non-specific protein binding and bacteria adhesion. Many methods have been involved in fabricating zwitterionic coatings. Nevertheless, the resulting zwitterionic polymer coatings are typically unstable with only short-term function, regardless of how they are immobilized on the surface. A novel zwitterionic macro-crosslinker was developed and applied to fabricate durable non-fouling coatings on a polyurethane substrate. The zwitterionic macro-crosslinker coating exhibited superior durability over the traditional brush polymer coating and was able to retain its non-fouling property even after weeks of shearing in flowing liquid.

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