472714 Membrane Assisted Crystallization: Process Model and Antisovlent Crystallization Control for Continuous Pharmaceuticals Manufacture

Wednesday, November 16, 2016: 1:35 PM
Cyril Magnin III (Parc 55 San Francisco)
Xiaobin Jiang1, Gaohong He1 and Linghan Tuo2, (1)Dept. of Chemical Engineering, Dalian University of Technology, Dalian, China, (2)Dalian University of Technology, Dalian, China

Membrane assisted crystallization: process model and antisovlent crystallization control for continuous pharmaceuticals manufacture

Xiaobin Jiang*, Gaohong He*, Linghan Tuo

State Key Laboratory of Fine Chemicals, Research and Development Center of Membrane Science and Technology, School of Chemical Engineering, Dalian University of Technology, Dalian, P. R. China

*Corresponding author: Email: xbjiang@dlut.edu.cn, hgaohong@dlut.edu.cn


Membrane assisted crystallization (MAC) has furnished a great progress in seawater desalination, brine treatment, wastewater recovery and crystallization control in recent decade, due to its advantages on utilizing low grade energy, promoting nucleation, controlling crystallization, etc [1,2]. Systematically frameworks and methods revolved MAC will be developed that can address the challenges in seawater treatment, brine wastewater recovery, fine crystals manufacture and biomolecular crystallization, etc [3].

In this paper, the process model combined membrane assisted crystallization, which involved the evaluation of the transmembrane flux and nucleation/growth rate will be established. The advantages of MAC on supersaturation degree control, nucleation kinetic and crystal size distribution modification will be revealed and investigated. The impact of the desired membrane property on the nucleation control was discussed in details.

On the basis of authors previous work [4,5], the membrane distillation crystallization is introduced to the antisolvent crystallization process to validate the developed model and the impact of membrane participant mass transfer process on continuous crystallization process control. The equivalent supersaturated degree was introduced to evaluate the controlling accuracy of MAC process and the stability of the control strategy. Due to the micrometer scale porous channel of the membrane, the micro mixing can be significantly improved and the mass tranfer control accuracy can be improved by 1 or 2 order of magnitudes compared to the existing droplet method with the millimeter scale mixing.

As a potential high accuacy control approach of antisolvent crystallizaiton, the MAC assisted antisolvent crystallization can be utilized in continuous and scale-up crystallization. These demands are especially significant in the area that have strict requirements on excellent, steady crystal qualities and robust crystallization control (pharmaceuticals crystallization, fine chemicals preparation, e.g.).

In addtion, these findings can drive the development of the comprehensive understanding on the complex nucleation mechanism under the heterogeneous chemical interface and confined environment. Further studies in this domain will be important for furthering the landscape of MAC application and the potential research results may provide conclusive evidence on the nucleation mechanism in heterogeneous phases[7-8], which is the one of the core concerns in nucleation theory.


This work is supported by National Natural Science Foundation of China (Grant No. 21306017, 21527812), Program for Changjiang Scholars and Support Project of the China Petroleum and Chemical Corporation (X514001).


[1] Edwie, F., Chung, T.-S.: Development of simultaneous membrane distillation¨Ccrystallization (SMDC) technology for treatment of saturated brine. Chem. Eng. Sci. 98, 160-172 (2013).

[2] Wang, P., Chung, T.-S.: Recent advances in membrane distillation processes: Membrane development, configuration design and application exploring. J. Membrane Sci. 474, 39-56 (2015).

[3] Chabanon, E., Mangin, D., Charcosset, C.: Membranes and crystallization processes: State of the art and prospects. J. Membrane Sci. 509, 57-67 (2016).

[4] Jiang, X., Ruan, X., Xiao, W., Lu, D., He, G.: A novel membrane distillation response technology for nucleation detection, metastable zone width measurement and analysis. Chem. Eng. Sci. 134, 671-680 (2015).

[5] Jiang, X., Lu, D., Xiao, W., Ruan, X., Fang, J., He, G.: Membrane Assisted Cooling Crystallization: Process Model, Nucleation, Metastable Zone, and Crystal Size Distribution. AIChE Journal 3, 829-841 (2016).

[6] Chabanon, E., Mangin, D., Charcosset, C.: Membranes and crystallization processes: State of the art and prospects. J. Membrane Sci. 509, 57-67 (2016).

[7] Diao, Y., Harada, T., Myerson, A. S.; Hatton, T. A.; Trout, B. L.: The role of nanopore shape in surface-induced crystallization. Nat. Mater. 10, 867-871 (2011).

[8] Myerson, A. S.; Trout, B. L., Nucleation from Solution. Science 341, 855-856 (2013).

Fig. 1 Schematic diagram of the antisolvent crystallization assisted by MAC technology.




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