471963 Aggregation-Induced Emission of Hydrophobically-Modified Metal Clusters in Lipid Nanodiscs

Thursday, November 17, 2016: 2:22 PM
Golden Gate 6 (Hilton San Francisco Union Square)
Armin Tahmasbi Rad1, Justin Letendre1, Elena Dormidontova2, Flavio Maran3, T. J. Mountziaris4 and Mu-Ping Nieh5, (1)Biomedical Engineering, University of Connecticut, Storrs, CT, (2)Physics, University of Connecticut, Storrs, CT, (3)Chemistry, University of Padova, Padova, Italy, (4)Department of Chemical Engineering, University of Massachusetts, Amherst, MA, (5)Chemical & Biomolecular Engineering, University of Connecticut, Storrs, CT

Biocompatible lipid-based nanodiscs (also known as “bicelles”) showed superior cellular uptake compared with liposomes of a similar length scale [1]. In this presentation we will demonstrate that bicelles can entrap nanometer-sized monolayer protected gold clusters (Au-MPCs) or hydrophobically-modified quantum dot (ZnSe/ZnS QD) through self-assembly, retaining reasonably uniform sizes (< 50 nm) as the bare ones. Aggregation-induced emission is observed in such nanoparticle-in-nanoparticle complexes (NP2) with nearly two orders of magnitude enhancement in luminescence in both cases of Au-MPC-NP2 and QD-NP2. The outcome of this research will provide the insight into the design of biosensing nanoparticles in a controllable and scalable manner.

[1] W. Aresh, Y. Liu, J. Sine, D. Thayer, A. Puri, Y. Huang, Y. Wang, M.-P. Nieh "The Morphology of Self-Assembled Lipid-Based Nanoparticles Affects Their Uptake by Cancer Cells" J. Biomed. Nanotech. (in press)

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