471193 Computational Fluid Dynamics (CFD) Guided Scale up of Cell Culture Bioreactors from Bench to Pilot to Commercial Scale

Monday, November 14, 2016
Grand Ballroom B (Hilton San Francisco Union Square)
William Tran1, Garima Chaudhary1, Jan-Erik Schaefer2, Erik Hasenfus2, Thomas Wucherpfennig2, Daniel Bock1 and Henry Lin1, (1)Pharmaceutical Development, Boehringer Ingelheim, Fremont, CA, (2)Pharmaceutical Development, Boehringer Ingelheim, Biberach, Germany

Computational fluid dynamics is a valuable tool for better understanding bioreactors and medium preparation tanks used for mammalian cell cultivation. Knowledge generated by CFD, such as on flow characteristics or on impeller mixing, aid in better transfer and scale up of cell culture processes.

This study used single phase simulations to predict power input and mixing time of production bioreactors at different scales. Impeller power numbers generated by CFD were compared across sites and assessed against historical vendor values to align cross-site scale up parameters. Approaches to applying CFD to large scale cell culture bioreactors will be discussed.

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See more of this Session: Poster Session: Pharmaceutical
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum