470461 Investigation of the Dfferences in Material Properties Between Amorphous Dispersions Created By Conventional Methods and High-Shear Co-Precipitation
In this work we present the characterization and analysis of a co-precipitated solid dispersion exhibiting significant differences in properties compared to equivalent dispersions, prepared via spray-drying and hot-melt extrusion. These differences extend across the full spectrum of “fundamental” characteristics, including morphology, true density, glass transition temperature and enthalpy, as well as indirect, “performance-based” properties, such as compactability and dissolution. A large collection of “orthogonal” techniques is brought to bear in the analysis of the material and the elucidation of the physical processes underlying these differences in properties.
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