470115 Tablet Compression Scale-up Risk Assessment Using a Model Based Approach

Wednesday, November 16, 2016: 9:14 AM
Union Square 3 & 4 (Hilton San Francisco Union Square)
Keirnan LaMarche, Drug Product Science and Technology, Bristol-Myers Squibb, New Brunswick, NJ and Trinkle David, Bristol Myers Squibb, New Brunswick, NJ

Scale-up of processes involves uncertainties from many sources: material properties, equipment design, operation parameters, etc. The use of several models, even simple models, can constrain risks and predict failures before they occur. This talk will focus on the use of modeling in conjunction with small scale experimentation as a predictive methodology to estimate and reduce risks due to the scale-up of the tablet compaction process.

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