468678 A Study of the Effects of Heat Therapy through Thermomechanical Coupling on Action Potential Properties and Spiral Wave Dynamics in a Cardiac Electromechanical Model
In this work, we introduce a thermo-electromechanical model for cardiac tissue, which is provided by thermomechanical coupling. Mathematically, this mechanism of thermomechanical coupling is based on the theory of thermoelasticity . The electrical activity is represented by the Luo-Rudy  model, and the mechanical properties are described using the Mooney-Rivlin material response . The active tension that couples the electrophysiological model with the cardiac mechanics model is generated using the Niederer-Hunter-Smith  model which is the most advanced model, including all features contained in other models. We apply the model to study how thermomechanical coupling affect the action potential shape, restitution properties, and dynamics of spiral waves. We show that deformation caused by heat transfer through the thermomechanical coupling affect these properties via MEF.
To the authors' best knowledge, this is the first work that studies the effects of coupling the heat with the soft tissue mechanics of the heart on the properties and dynamics of action potential. This will serve to demonstrate that heat therapy can be pursued in the design of therapeutic strategies and algorithms for implantable devices capable of preventing or treating life-threatening cardiac arrhythmias, VF for example, where the electrical therapy is currently the most widely used treatment.
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