468572 Simulating Airflow in Human and Nonhuman Primate Airways with Applications to Aerosolized Drug Delivery Animal Testing
In the respiratory tract, inhaled aerosols must navigate the airways of the body and be deposited in targeted ways to maximize drug efficiency. Accurate analysis of drug efficacy and dosage requires an understanding of where these particles go upon inhalation. We report deposition fractions in airways across a range of particle sizes, breathing rates, and in numerous lung geometries. These computational results are validated with PET/CT experimental results. We compare these results with our previous report to show that differences in length scales between species produce fundamentally different time-dependent flow behavior and aerosol deposition mechanisms. Particle filtering in the nasal passages are reported for both species. In addition to patient-specific lungs, we compare and contrast the flow through statistically averaged bronchial trees of both humans and rhesus monkeys.
Additionally, we report on the success of novel simulation techniques that allow us to simulate deposition during a full inhalation/exhalation cycle. We employ advanced boundary conditions constructed using reduced-order modeling of the lower generations of the bifurcating airways and alveoli.