468269 Identification of Magnetic Nanoparticles to Eradicate Cancer Cells Using the Hyperthermia Approach – a Computational Search Approach

Tuesday, November 15, 2016: 2:30 PM
Union Square 3 & 4 (Hilton San Francisco Union Square)
Shounak Datta and Mario Richard Eden, Department of Chemical Engineering, Auburn University, Auburn, AL

In recent years, nanomaterials have received significant attention due to their unique properties. Magnetic nanoparticles (MNPs) in particular are of high importance due to their magnetic properties. These particles are being tested for various applications including cancer cell detection and targeted cell temperature increase.

Hyperthermia treatment of cancer cells has been one of the most promising ideas of last decade. The theory is to design materials which are very efficient in targeting the cancer cells. The designed particles are to have magnetic properties such that at certain magnetic field conditions the particle develops a higher temperature than the surrounding atmosphere/environment.

This project aims to investigate a way to model magnetic nanoparticle behavior in the presence of different magnitudes of magnetic fields. The aim is to model Brownian and Neel relaxation parameters to determine the heat generated by different MNPs to study which is best suited for hyperthermia treatment of cancer cells. For that, approaches were used to determine AC susceptibility of the out-of-phase particles which was then used in a 3-D model containing healthy and cancer cell. The 3-D model is used to determine temperature output for such materials in the presence of an optimal magnetic field.


Selected References:

  1. Rudolf Hergt, Silvio Dutz, Robert Muller, Matthias Zeisberger, Magnetic particle hyperthermia: nanoparticle magnetism and materias development for cancer treatment, 2006, J. Phys.:Condens. Matter, Vol 18, S2919-S2934.
  2. Shihu Wang and Elena E. Dormidontova, Nanoparticle Design Optimization for Enhanced Targeting: Monte Carlo Simulations, 2010, Biomacromlecules, Vol 11, 1785-1795
  3. Andreas Jordan, Regina Scholz, Peter Wust, Horst Fahling, Ronald Felix, Magnetic fluid hyperthermia: Cancer treatment with AC magnetic field induced excitation o biocompatible supermagnetic nanoparticles, 1999, Journal of Magnetism and Magnetic Materials, Vol 201, 413-419
  4. Stefan T Bromley, Iberio de P. R, Moreira, Konstantin M. Neyman, Francese Illas, Approaching nanoscale oxides: models and theoretical methods, 2009, Chem. Soc. Rev., Vol 38, 2657-2670.

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