468173 Mussel-Inspired Injectable Gelatin-Methacryloyl Bioadhesive for Minimally Invasive Suregry

Wednesday, November 16, 2016: 5:15 PM
Golden Gate 2 (Hilton San Francisco Union Square)
Iman Noshadi Sr.1, Arameh Masoumi2, Iman Ashtiani Abdi3, Mahboobeh Nabavinia2, Ali Tamayol2, Nasim Annabi2 and Ali Khademhosseini2, (1)Northeastern University, BOSTON, MA, (2)Wyss institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, (3)Wyss institute for Biologically Inspired Engineering, Harvard University, MA

Wet tissue adhesion required in many surgeries such as those for internal organs. The current surgical adhesives are not ideal. Developing surgical adhesives with strong wet tissue adhesion, controlled mechanical properties, and excellent biocompatibility has been a significant challenge. Herein, we report for the first time visible light crosslinkable catechol conjugated Gelatin (GelMAC) adhesive for internal surgeries. Compare to commercially available adhesive, GelMAC showed superior wet tissue adhesion, controlled mechanical properties and high in vitro Cytocompatibility. Three different ex-vivo animal models were used to evaluate the feasibility and effectiveness of GelMAC as minimally invasive sealants in the absence of any additional conventional surgical methods, such as suturing or stapling. Our results show that GelMAC is highly translational and could have broad impact on surgeries where surgical tissue adhesives and sealants are used.

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See more of this Session: Biomacromolecular Gels
See more of this Group/Topical: Materials Engineering and Sciences Division