468059 Extending the Dynamic Range of Nanosensors
However, one of the key limitations of these sensors is the dynamic range is often limited relative to the desired range for physiological application. There are two key causes for this limitation: the optode mechanism and the available selection of chromoionophores. Relative to a similar technology, ion-selective electrodes, the pH based mechanism inherently limits dynamic range based on the pKa of the chromoionophore. In this work we control the dynamic range of these nanosensors through altering the formulation of the optode components. This results in nanosensors with tunable and extended dynamic ranges – a necessary step in measurement cases where concentrations change by more than one order of magnitude.
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