467999 An Ammonia Sensor for a Handheld Analyzer for Non-Invasive, Real-Time Monitoring of Kidney and Liver Disorders

Tuesday, November 15, 2016: 8:58 AM
Divisadero (Parc 55 San Francisco)
Nai-Yuan Liu1,2, Tianmiao Lai1, Afsaneh Khosravi1, Pinar Cay Durgun1, Mary Laura Lind1, Erica Forzani1,2 and Leslie Thomas3, (1)School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, (2)Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, Tempe, AZ, (3)Mayo Clinic, AZ

A small device that could reliably measure urine ammonia in either the outpatient or inpatient settings would have a myriad of clinical applications. Diagnosis and management of disorders that impact absolute or relative changes in renal excretion of ammonia, including conditions that alter systemic acid/base homeostasis and diseases of the kidney and liver, would be greatly aided by such a device. However, traditional practical and technical limitations of urine ammonia measurement have impeded the use of urine ammonia as a routinely employed biomarker. This project is focused on the development of analyzer technology directed at ammonia measurement and the implementation of this analyzer into a practical handheld device prototype. The proposed technology is based on a unique hybrid sensor array capable of quick, precise, and reliable measurement. The analyzer will be capable of being applied in two broad formats: 1) a handheld device for outpatient or inpatient applications requiring less frequent (e.g., daily) monitoring, and 2) a urinary catheter device for semi-continuous measurement for inpatient applications requiring intensive serial monitoring. The miniaturized, low cost, easy to use handheld device prototype will utilize solid-state electronics with a high level of integration. Furthermore, the prototype will connect wirelessly to a centralized data display and storage unit (e.g., cellular phone), allowing a clinician to easily track an individual or a group of patients. This work shows the prototype of the sensor, and its capability for ammonia quantification in biological samples in real-time scale. The sensor shows fast and reversible response.

Extended Abstract: File Not Uploaded
See more of this Session: Biosensor Devices: Applications
See more of this Group/Topical: Topical Conference: Sensors