467302 Characterization of Lab and Plant Reactors Using Fast Competitive Reactions and a Predictive Model
The fast competitive reaction system involving neutralization and ester hydrolysis (a so-called ‘Bourne Reaction’, ref 1) among other techniques has been used by Pfizer to study mixing characteristics in several common lab reactors used for routine development of chemical processes and also for a series of plant reactors. The final product distribution after running the reaction in fed batch mode reflects the history of relative mixing and reaction rates in the plume or reaction zone that forms near the feed location.
In general, a critical feed time can be identified and longer feed times represent micromixing-controlled conditions. It is possible using a predictive model containing both kinetics and mixing parameters to estimate the product distribution as a function of feed time and mixing energy dissipation rate. This latter parameter, often referred to as epsilon, with units of W/kg, is of interest for a wide range of mixing phenomena. Using the predictive model together with measured product distribution, it is possible to estimate the corresponding epsilon.
We will present and discuss results for different reactors and operating conditions and also how best to use predictive models to design and analyse the experiments, which require a good dynamic range of selectivity to be informative. We will compare mixing performance at operating conditions that are commonly used in the lab and plant. Finally, we will extract some guidelines towards obtaining equivalent mixing between lab and plant reactors.
- Investigation of micromixing in stirred tank reactors using parallel reactions, John R. Bourne , Shengyao Yu, Ind. Eng. Chem. Res., 1994, 33 (1), pp 41–55
See more of this Group/Topical: North American Mixing Forum