462399 Scaling Intra-Tablet Coating Variability

Wednesday, November 16, 2016: 1:58 PM
Continental 5 (Hilton San Francisco Union Square)
Siddhartha Agarwal, Mechanical Engineering, Purdue University, West Lafayette, IN and Carl Wassgren, School of Mechanical Engineering, Purdue University, West Lafayette, IN

Pharmaceutical tablets usually exhibit variability in coating thickness, both across individual tablets as well as over a single tablet’s surface. In this work, the coefficient of variation in coating thickness, referred to as intra-tablet coating variability, is examined as a function of processing scale. The discrete element method (DEM) is used to simulate the dynamics of two different tablet shapes in coating pans of four different sizes. The asymptotic intra-tablet coating variability is observed to increase with increasing pan size. Studies designed to explain the observed trend are also presented.

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