461601 Contact Secondary Nucleation and Self Assembled Monolayers

Monday, November 14, 2016
Embarcadero (Parc 55 San Francisco)
Hideomi Kijima1,2 and Allan S. Myerson1, (1)Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (2)Ono Pharmaceutical Co., Ltd., Osaka, Japan

Understanding and controlling nucleation is a long-standing issue in the field of crystallization and solid state chemistry. In this work we use gold-thiol self-assembled monolayers (SAMs) as hetero-surfaces and induce nucleation by contact force to understand the mechanism of contact-induced heterogeneous nucleation, on different SAMs. A set of contact force nucleation experiments in aqueous glycine solution with SAMs of different functional groups has been performed and compared to a control. Results demonstrate significant reduction in nucleation induction time as well as formation of the beta polymorph of glycine a low supersaturations.

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See more of this Session: Poster Session: AES
See more of this Group/Topical: 2016 Annual Meeting of the AES Electrophoresis Society