461590 PAT Enabled Drying Platform for API Process Development – Investigation of Solvent Trapping Associated with Form Transition and Crystal Collapse during Drying
A PAT enabled drying platform was used and advanced laboratory methodologies were developed to capture detailed process data and gain a fundamental understanding of the drying process, test various theories for solvent trapping, and evaluate drying from an alternative solvent system. Experiments performed led to increased process understanding, identification of conditions needed for successful drying, and ultimate process selection to improve process efficiency, robustness, and portability. The newly developed process was successfully demonstrated at pilot plant scale with performance in line with model projections. Results of this investigation and the methods applied will be described in detail during this presentation.