461114 Solid-in-Oil (S/O) Nanodispersions for Transdermal Cancer Immunotherapy
In this study, we applied this technique to a cancer antigen and aimed to develop an effective transcutaneous cancer vaccine. We chose the melanoma, a kind of the skin cancer, to evaluate the cancer immunity. Because a melanoma antigen, TRP-2 peptide, has low solubility in water, we added lysine residues to the N-terminus of the peptide and the newly developed peptide antigen, K-TRP-2, was used as a melanoma antigen. In addition, we tried the use of R-848 as hydrophobic adjuvant to induce stronger immunity. The in vivo experiment revealed the effective prevention of tumor and the metastasis was achieved by S/O formulation containing R-848.
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