461094 Preparation of Colloidal Microcapsules for Controlled Drug Delivery Systems
As well as NPs are being used in several areas including medical and pharmaceutical individually, more versatile systems can be established via self-assembly of NPs. Colloidal microcapsules are one of the most interested part of these self-assembled structures whose shell side are composed of nanoparticles . Layer-by-layer method (LbL) is one of the most used methods in the production of self-assembled structures. These self-assembled structures, independent from their single form, possess attractive properties such as high stability, enhanced functionality and increased loading capacity. Additionally, using pharmaceutically active ingredients such as drug crystals or drug loaded nanoparticles as the core material of colloidal microcapsules provides controlled release of the encapsulated material with the help of shell layers . In this study, novel self-assembled colloidal microcapsules by using Ibuprofen crystals or CaCO3 nanoparticles as core material and SLNs as shell material were prepared by using LbL method. The performance of establishing the layers was monitored by measuring the change of zeta-potential values. Also the self-assembled structures were visualized with SEM. Controlled drug release from the microcapsules was monitored by using UV-visible spectroscopy. Due to several advantageous properties such as being composed of physiologically related lipids, possessing properties like small and adjustable structure, high surface area, enhanced stability, stimuli-responsivity and increased encapsulation efficiency, these unique systems will be an ideal alternative to the conventional nanocarriers, which are especially used in pharmaceutical and biomedical applications as controlled drug delivery agents.
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