460934 Multi-Layer Agent-Based Modeling of Vascularized Bone Regeneration within a Porous Biomaterial Scaffold with Growth Factor Gradient
We have previously developed an ABM to investigate angiogenesis (Mehdizadeh et al., 2013) and osteogenesis (Bayrak et al., 2014) in a porous, degradable biomaterial scaffold. In addition, a biomaterial system that creates gradients of growth factors within the porous scaffold was developed to accelerate scaffold vascularization (Akar et al., 2015). The current work extends and modifies the ABM to simulate the interaction between stem cells and growth factors. Both endogenous and exogenous growth factor release are considered to investigate the effects on bone tissue regeneration. The multi-layer ABM is utilized to investigate optimum growth factor gradient properties and scaffold geometrical structure to form clinical size vascularized bone tissue.
Bayrak, E. S., Mehdizadeh, H., Akar, B., Somo, S. I., Brey, E. M. & Cinar, A. Agent-Based Modeling Of Osteogenic Differentiation Of Mesenchymal Stem Cells In Porous Biomaterials. Engineering In Medicine And Biology Society (EMBC), 2014 36th Annual International Conference Of The IEEE, 2014. IEEE, 2924-2927.
Mehdizadeh, H., Somo, S., Bayrak, E. S., Brey, E. M. & Cinar, A. 2013. Three-Dimensional Modeling of Angiogenesis In Porous Biomaterial Scaffolds. Biomaterials, 34, 2875-2887.
Akar, B., Jiang, B., Somo, S.I., Appel, A.A., Larson, J.C., Tichauer, K.M. and Brey, E.M., 2015. Biomaterials with persistent growth factor gradients in vivo accelerate vascularized tissue formation. Biomaterials, 72, pp.61-73.
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