460002 Computational Solid‐State Chemistry Applications in Pharmaceutical Industry

Monday, November 14, 2016: 3:15 PM
Union Square 5 & 6 (Hilton San Francisco Union Square)
Yuriy Abramov, Pfizer, Groton, CT

Given the complexity of the pharmaceutical solid‐state landscape and challenges facing the pharmaceutical industry, an accelerated Drug Development greatly benefits from guidance provided by computational methods. The emerging field of Computational Pharmaceutical Solid State Chemistry covers the whole spectrum of state‐of‐the‐art computational approaches, which are used to support all steps related to the development of solid‐state pharmaceuticals.1 This work will consider virtual screening approaches allowing solvent selection for impurity purge, coformer selection for cocrystallization and solid solvate/hydrate formation screening.

1. Abramov, Y.A., Ed. Computational Pharmaceutical Solid State Chemistry, John Wiley & Sons, 2016.

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See more of this Session: Pharmaceutical Process Development & Pilot Plants
See more of this Group/Topical: Process Development Division