459850 Dissolvable Microcarriers for Efficient Cell Production and Recovery

Monday, November 14, 2016
Grand Ballroom B (Hilton San Francisco Union Square)
Yue Zhou1, Jennifer L. Weber1, Kathleen Krebs1, Martial Hervy2, Marylene Pecheul2, Corinne Walerack2, David Henry2, Marie-Maud Bear2 and Stephen Caracci1, (1)Life Sciences Development, Corning Inc., Corning, NY, (2)Corning European Technology Center, Corning Inc, Avon, France


Cell scale-up on microcarriers is an increasingly important technique for bioprocess applications. However, the harvest, separation, and concentration of final product (e.g. cell, virus, or antibody) can be time and resource consuming. To address these issues, Corning has developed a new generation of microcarriers that can be quickly dissolved, allowing easy collection of grown cells or secreted products without the need for microcarrier separation. Here we present unique properties and potential applications for dissolvable microcarriers. Human mesenchymal stem cells (hMSCs) and Vero were grown in spinner flask cultures or bioreactors on dissolvable microcarriers. For all cell types evaluated, growth performance on dissolvable microcarriers was equivalent to other commercially available microcarriers, and high quality cells were recovered without the need for microcarrier separation.

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See more of this Session: Poster Session: Pharmaceutical
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum