458027 Synthesis of Cellulose-Based Injectable Hydrogel Composite for pH-Responsive Drug Delivery

Monday, November 14, 2016: 4:55 PM
Lombard (Hilton San Francisco Union Square)
Nusheng Chen, Agricultural and Biological Engineering, University of Florida, Gainesville, FL and Zhaohui Tong, Agricultural and Biological Engineering Department, IFAS,, University of Florida, Gainesville, FL

Abstract: Localized drug delivery, and prolonged, stimulus-driven release are approaches to maximize the function of drugs and minimize their side effects. This study developed a novel cellulose-based injectable hydrogel composite system containing pH responsive poly (ethylene oxide)-block-poly (2-(diisopropylamino) ethyl methacrylate) (PEO-b-PDPA) copolymer micelles for localized delivery and pH-triggered release. First, covalently in situ generated hydrogels were constructed by mixing hydrazide-modified carboxymethyl cellulose (CMC-NH2) with oxidized carboxymethyl cellulose (CMC-CHO). The resultant hydrogels could be well tuned in the aspects of gelation time, degradation profile, and mechanical properties. Then, the pH-responsible copolymer PEO-b-PDPA was introduced to enhance the loading of hydrophobic substances in hydrogels as well as a pH-triggered release, which was demonstrated by fluorescent spectroscopy using Nile Red as a model drug. In addition, the results demonstrated that the hydrogel itself could act as a second diffusion barrier to reduce the drug release rate. The cell viability tests showed that both CMC-NH2 and hydrogels possessed excellent biocompatibility, while CMC-CHO was cytotoxic at a relative high concentration.

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