454210 Magnetic Superbasic Nano Catalysts for Rapid Catalyst Removal and Direct Product Isolation
Here we present an organic superbase, coupled to magnetic nanoparticles, with stability amenable for use in challenging reaction conditions. We further show that such an easy-to-separate reagent is useful in a number of condensation reactions and simplifies work-up and product isolation The immobilized magnetic superbase reagent was tested in the base-catalyzed Knoevenagel and Claisen-Schmidt type condensations and showed conversions up to 99%. High yields up to 97 % of isolated product could be obtained by simple recrystallization without using column chromatography. Recycling of the catalyst was simple and fast with insignificant decrease in catalytic activity.
Schneider, E. M.; Raso, R. A.; Hofer, C. J.; Zeltner, M.; Stettler, R. D.; Hess, S. C.; Grass, R. N.; Stark, W. J. The Journal of Organic Chemistry 2014, 79, 10908
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