697 Model Based Integrated Design of Pharmaceutical Drug Substance and Drug Product Processes II

Thursday, November 12, 2015: 12:30 PM - 3:00 PM
Ballroom B (Salt Palace Convention Center)

Description:
This session seeks contributions where modeling-aided approaches as well as optimization techniques have been applied for decision making in the design and development of pharmaceutical intermediates, drug substances, and/or drug products. Modeling research including CFD, DEM, FEM, Monte Carlo, Population balance, thermodynamic, kinetic or other approaches are welcome. Authors are encouraged to highlight integration to upstream and downstream operations as well as Quality by Design considerations. Authors from both drug substance and drug product sides of the business are encouraged to submit an abstract.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)
Chair:
Luke Achenie Email: achenie@vt.edu
Co-Chair:
Joshua Selekman Email: Joshua.Selekman@bms.com
- indicates paper has an Extended Abstract file available on CD.



12:30 PM
(697a) Implementation of a Reduced System Model to a Continuous Direct Compression Manufacturing Process
Adam S. Butterbaugh, Salvador García-Muñoz, Carla Luciani, Ian Leavesley and Ahmad Almaya


12:50 PM
(697b) Flowsheet Modeling for Oral Solid Drug Product Manufacturing
Zilong Wang, M. Sebastian Escotet-Espinoza, Ravendra Singh, Fernando J. Muzzio and Marianthi Ierapetritou


1:10 PM
(697c) A Multi-Fidelity Mechanistic Modeling Framework for Wet Granulation Processes: Characterization and Technology Transfer
Dana Barrasso, David Slade and Sean K. Bermingham


1:30 PM
(697d) Prediction of Lubrication-Based Tensile Strength Reduction Using a Compartment Modeling Approach
William R. Ketterhagen, Matthew P. Mullarney, John Kresevic and Daniel O. Blackwood

File available
1:50 PM
(697e) FEM Simulations on Tablet Impact
Jie Ren, Gerard Klinzing, Steven Persak and Adam Procopio


2:10 PM
(697f) Dynamic Modeling and Advanced Control of Tablet Press
Ravendra Singh, M. Sebastian Escotet-Espinoza, Shishir Vadodaria, Jun Zhang, Fernando J. Muzzio, Rohit Ramachandran and Marianthi Ierapetritou


2:30 PM
(697g) Data Driven Predictive Modeling of Formulation and Process Conditions of Pharmaceutical Spray Dried Intermediates
Elise Miller
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