452 Applications of Materials Science in Pharmaceutical Process Development

Wednesday, November 11, 2015: 8:30 AM - 11:00 AM
Ballroom D (Salt Palace Convention Center)

Material science understanding is a key factor to consider in drug substance and drug product process development. The material properties for the API, excipients, drug product intermediates and final tablets can influence the process and product performance. This session focuses on the application of material science to guide drug substance and drug product development. Of particular interest is work related to new measurement techniques to elucidate key material attributes impacting performance or novel uses of material property data to gain further process understanding.

Pharmaceutical Discovery, Development and Manufacturing Forum
Pharmaceuticals (15B)
Jason Sweeney Email: jason.sweeney@bms.com
Robert E. Yule Email: robert.e.yule@gsk.com
- indicates paper has an Extended Abstract file available on CD.

8:30 AM
(452a) Effects of Operating Parameters on Tablet Quality in a Continuous Manufacturing Line
Golshid Keyvan, Xue Liu, Sonia Razavi, Alberto Cuitiņo and Fernando. J Muzzio

8:55 AM
(452b) Enhanced Spray Drying Throughput with High Productivity Hypromellose Acetate Succinate
William Porter III, Oliver Petermann, Meinolf Brackhagen, Matthias Sprehe, Matthias Knarr, Wes Spaulding, Rick F. Falk, Ravi Reddy, Richard Nkansah, Brice Murri and Michael Morgen

9:20 AM
(452c) Measuring Blend Hydrophobicity By Single Droplet Penetration Technique
Yifan Wang, Zhanjie Liu, Gerardo Callegari, German Drazer and Fernando J. Muzzio

9:45 AM

File available
10:10 AM
(452e) Pharmaceutical Processes Selection from Shear Cell Analysis and Compaction Simulation
Don Clancy, Sayantan Chattoraj, Laura Wehmeyer, Robert E. Yule and Fran Muller