223 PAT for Crystallization Development and Manufacturing

Monday, November 9, 2015: 3:15 PM - 5:45 PM
Salon J (Salt Lake Marriott Downtown at City Creek)

Description:
The session is focused on providing examples where Process Analytical Technologies (PAT) have been used in the development of crystallization processes. PAT applications may include various spectroscopy (FTIR, NIR, Raman), particle size and counting techniques (FBRM, PVM), and other on-line or in-line monitoring or sensing techniques. Novel approaches and methodologies to drive crystallization development or control manufacturing crystallization processes are of particular interest.

Sponsor:
Process Research and Innovation
Co-Sponsor(s):
Crystallization and Evaporation (02B), Pharmaceutical Discovery, Development and Manufacturing Forum (26)
Chair:
James C. Marek Email: james.marek@abbvie.com
Co-chairs:
Seth Huggins Email: shuggins@amgen.com
Vidya Iyer Email: Vidya.Iyer@bms.com


3:15 PM
(223a) Efficient Calibration for in-Situ Measuring L-Glutamic Acid Solution Concentration Via ATR-FTIR
Tao Liu, Fangkun Zhang, Xue Z. Wang and Cai Y. Ma


3:40 PM
(223b) Optimization of a Reactive Crystallization Using a Pharmaceutical Engineering Approach
Vidya Iyer, Andrew Glace, William Gallagher, Brendan C. Mack, Junying Fan, Jason Zhu, Benjamin Cohen, Scott Jones and David Conlon


4:05 PM
(223c) Monitoring Co-Crystal Purity with on-Line Raman Spectrascopy
Fei Sheng, Pui Shan Chow, Zai Qun Yu and Reginald Tan


4:30 PM
(223d) Automated Multi-Loop Direct Nucleation Control Using Focused Beam Reflectance Measurement in Multistage Continuous Mixed Suspension Mixed Product Removal Crystallizer
Yang Yang, Liangcheng Song and Zoltan K. Nagy


4:55 PM
(223e) Digital Phase Diagram of K2SO4-KOH-H2O and Crystal Growth of K2SO4 in the Strong Alkali Solution
Mengjie Luo, Chenglin Liu, Jin Xue, Ping Li and Jian-Guo Yu


5:20 PM
(223f) Controlling Crystal Size, Shape and Purity during Crystallization By Using Additives
Akos Borsos and Zoltan K. Nagy
See more of this Group/Topical: Process Development Division
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