394 Crystallization Process Development

Tuesday, November 10, 2015: 3:15 PM - 5:45 PM
155D (Salt Palace Convention Center)

Crystallization Process Development Crystallization is an industrially important unit operation for isolation and purification of a wide range of chemical products, including pharmaceuticals and fine chemicals. Developing a crystallization process can be challenging, often complicated by multiple components and requirements that the solids are consistently isolated in the desired polymorphic forms, compounds, adducts, or solvates. Control of particle size distribution may be needed to avoid difficult filtrations or high impurity content. This session welcomes contributions related to theoretical as well as practical approaches to crystallization process development, including techniques and tools that can lead to more efficient development of robust crystallization processes. Case studies and examples of how commercial crystallization processes are developed, and papers which describe the design and operation of batch or continuous crystallization processes are particularly encouraged.

Crystallization and Evaporation
Solids Flow, Handling and Processing (03C), Process Research and Innovation (12A)
Chenchi Wang Email: chenchi.wang@bms.com
Ryan Snyder Email: rcs048@bucknell.edu
James C. Marek Email: james.marek@abbvie.com
- indicates paper has an Extended Abstract file available on CD.

3:20 PM

3:40 PM
(394b) Indirect Ultrasonication in Continuous Slug-Flow Crystallization
Mo Jiang, Charles D. Papageorgiou, Josh Waetzig, Andrew Hardy, Marianne Langston and Richard D. Braatz

4:00 PM
(394c) Kinetic Modeling and Scaleup Assessment of Seeded Solvent Mediated Form Conversion
David Willcox, Hoa Luong, Praveen Mudunuri, Justin Pritchard, Stefanie Roeper, Phillip Snyder, Brian Phenix, Nicole Lahousse, Martin Warman and Brian Luisi

4:20 PM
(394d) Improving the Separation of Organic Small Molecules Purified Via Sublimation
Nathan T. Morgan, Yi Zhang, Matthew L. Grandbois, Bruce M. Bell, Russell J. Holmes and Edward L. Cussler

See more of this Group/Topical: Separations Division