267 Applications of Continuous Processing in the Manufacture of Pharmaceuticals: Drug Substance I

Tuesday, November 10, 2015: 8:30 AM - 11:00 AM
Ballroom B (Salt Palace Convention Center)

Enabled by new technology, continuous processing offers new methods of increasing safety, selectivity, and yield for chemical and biochemical processes. Improved control over process streams enables operation at extreme conditions with reduced sensitivity to scale-up effects. This session will focus on applications of continuous processing to the production of drug substances or their intermediates. The session is keen to attract papers which provide an insight to continuous processing state of the art and its association to industrial application.

Pharmaceutical Discovery, Development and Manufacturing Forum
Pharmaceuticals (15B)
Mark Barrett Email: mark.barrett@approcess.com
Suhas Shelukar Email: sshelukar@adamaspharma.com

8:30 AM
(267a) Development and Scale up of a Continuous Flow Reaction for API Intermediate Manufacture
Jonathan P. McMullen, Christopher H. Marton and Benjamin Sherry

9:20 AM
(267c) Development and Scale-up of Acrylamide Formation Using an Impinging Jet
Daniel D. Caspi, Benoit Cardinal-David and Alexander D. Huters

9:45 AM
(267d) Robust Parallelization of Triphasic Micro/Millireactors for Sustainable Pharmaceutical Manufacturing
Swee Kun Yap, Wai Kuan Wong, Nicholas Xiang Yang Ng, Ning Yan and Saif A. Khan

10:10 AM
(267e) Multi-Step Continuous GMP Production of a Highly Potent Compound
Jennifer M. Groh, Kevin P. Cole, Bradley M. Campbell, Martin D. Johnson, Neil Kallman, David Mitchell and Christopher S. Polster

10:35 AM