441498 Dynamic Covalent Assembly of Peptoid-Based Ladder Oligomers

Sunday, November 8, 2015: 5:10 PM
253A (Salt Palace Convention Center)
Timothy F. Scott, Tao Wei, Megan Dunn and Jae Hwan Jung, Department of Chemical Engineering, University of Michigan, Ann Arbor, MI

Dynamic covalent chemistry, in conjunction with template-directed assembly, enables the fabrication of extended nanostructures that are both precise and tough. Here, we demonstrate the dynamic covalent assembly of peptoid-based molecular ladders with up to 12 rungs via scandium(III)-catalyzed imine metathesis by employing the principle of Vernier templating, where small precursor units with mismatched numbers of complementary functional groups are co-reacted to yield larger structures with sizes determined by the respective precursor functionalities. Owing to their monomer diversity and synthetic accessibility, sequence-specific oligopeptoids bearing dynamic covalent pendant groups were employed as precursors for molecular ladder fabrication.

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See more of this Session: Self-Assembled Biomaterials
See more of this Group/Topical: Nanoscale Science and Engineering Forum