437583 Recreating Natural Plant Processes in Bacteria for the Production of Complex Biomolecules

Wednesday, November 11, 2015: 9:49 AM
155A (Salt Palace Convention Center)
Christine Nicole S. Santos and Ajikumar Parayil, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA

Despite the potential utility of specialized secondary metabolites in a number of commercial applications (pharmaceuticals, consumer and food products, and industrial chemicals), their low abundance in nature presents a significant sourcing and economic obstacle for adoption.   Here, we describe the advantages of pairing multivariate modular metabolic engineering of bacteria with systems-level characterization of engineered strains by transcriptomics, proteomics, and metabolomics for expediting the development of economical and sustainable processes for the production of these complex biomolecules.

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