435239 Modulating Vibrio Cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

Monday, November 9, 2015: 10:30 AM
151D/E (Salt Palace Convention Center)
Robert K. Prud'homme, Chemical and Biological Engineering, Princeton University, Princeton, NJ

The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses five orders of magnitude higher than does the identically administered free CAI-1, and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.

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See more of this Session: Drug Delivery I
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division