431880 Encapsulation of Iron Oxide Nanoparticles into Poly(lactic acid) Micro/Nanoparticle System and Poly(lactic acid)/Polystyrene Bio-Blend Microparticle System

Thursday, November 12, 2015: 2:00 PM
253B (Salt Palace Convention Center)
Anna Song1, Shaowen Ji1, Joung Sook Hong2, Ankush A. Gokhale3 and Ilsoon Lee1, (1)Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, (2)Department of Chemical Engineering, Soongsil University, Seoul, South Korea, (3)Chemical Engineering & Materials Science, Michigan State University, East Lansing, MI

Magnetic iron oxide nanoparticles (IO NPs) have a wide application in biomedical engineering, catalysis, magnetic resonance imaging and so on. However, free IO NPs have several challenges such as aggregation and chemical activity, causing loss of magnetism and dispersibility. In order to protect naked IO NPs, a controllable process to encapsulate either hydrophobic or hydrophilic IO NPs into the hydrophobic biodegradable polymer micro/nanoparticles has been developed to meet various applications of magnetic nanoparticles. By applying the same experimental setup, we can generate polymer particles with different shapes and sizes, encapsulating either hydrophobic or hydrophilic NPs, by simply adjusting the water phase viscosity and the emulsion temperature. In this study, both a pure poly (lactic acid) (PLA) system and a bio-blend of poly(lactic acid)/polystyrene (PS) were employed to encapsulate hydrophobic (~5 nm) or hydrophilic (~10 nm) iron oxide nanoparticles (IO NPs). In order to encapsulate hydrophilic IO NPs, a water-in-oil-in-water (W/O/W) emulsion was formed via only one emulsion step. The transformation between hollow microparticles and solid nanospheres was realized by repeating the emulsion process between high temperature (HT) and room temperature (RT).  Hydrophobic IO NPs were encapsulated into nanospheres via an oil-in-water (O/W) emulsion or microparticles via W/O/W emulsion.

Extended Abstract: File Not Uploaded