427882 Amphiphilic Nanoparticles Control the Growth and Stability of Lipid Bilayers with Open Edges

Wednesday, November 11, 2015: 2:30 PM
Canyon B (Hilton Salt Lake City Center)
Sun Hae Ra Shin, Chemical Engineering, The Pennsylvania State University, University Park, PA, Hee Young Lee, Penn State University, University Park, PA and Kyle J. M. Bishop, Chemical Engineering, Penn State University, University Park, PA

Molecular amphiphiles self-assemble in polar media to form ordered structures such as micelles, vesicles, and membranes essential to a broad range of industrial and biological processes.  However, some of the more interesting architectures – such as bilayer sheets, helical ribbons, and hollow tubules – are inherently unstable owing to the presence of “open” edges that expose the hydrophobic bilayer core to the polar surroundings. Here, we describe a strategy to stabilize open bilayer structures using amphiphilic nanoparticle “surfactants” that present mixtures of hydrophilic and hydrophobic ligands on their surface. These particles can bind selectively to the open edge of bilayer membranes to stabilize otherwise transient amphiphile assemblies.  We show how such particles can precisely control the size of lipid tubules, how they can inhibit the formation of undesirable assemblies such as gallstone precursors, and how they can stabilize free-floating lipid “microdiscs”.

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See more of this Session: Self-Assembly in Solution
See more of this Group/Topical: Engineering Sciences and Fundamentals